I am looking at buying a bigger than stock DNA rear spoked wheel for my standard 98 Evo softail.

Can I run a 160mm rear tyre on a 4.25" X 18"   rear  rim  using  a chain final drive without clearance issues or modifications??

Thanks for any advice.

The Recommened Rim for 160 x 18 is 4.25 or 5

you might have some clearance issues with your rear guard,will fit with a chain or even late model belt. rear guard usually the only prob.

You can get a 200 with a 5.5 Rim on it by using a late model 19mm Belt and Pulley Theres heaps of room

No

I'VE done 2 using Stock Swingarm and 19mm Belt and Pulley 18 X 5.5 Rim and 200 Metzler